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Qualifications

Ph.D. Cell biology/Regenerative Medicine (Newcastle University)
M.Res. Medical and Molecular Biosciences (Newcastle University)
B.Sc. Hons. Neuroscience with Psychology (University of Aberdeen)

Responsibilities

Module Leader:

BI0H100 – Essentials of Science
BI1S54 – Biological Chemistry
BI2S113 – Frontiers in Biology
BI2S93 – Cellular Pathology and Disease Processes
BI3S71 – Clinical Biochemistry and Pharmacology
BI3D100 – Human Biology Research Project
BI3D101 – Medical Science Research Project
BI3D102 – Biology Research Project
BI3D103 – Wildlife Research Project
BI3D104 – Natural History Research Project

Teaching Contributions:

BI1S62 – Big Game Tracking (South Africa)
BI1S100 – Microorganisms and the Dynamic Cell
BI1S106 – Human Growth and Development
BI2S103 – Applied Physiology
BI2S119 – Human Form and Function
BI2S114 – Clinical Physiology
BI2S112 – Ethology
BI2S117 – Patterns in African Biodiversity

Current Research Students:
Undergraduates
Jacob Moorse (Biology BSc): Galvanotaxis of stem cells during large-scale tissue regeneration in planaria: the impact of polarised electric fields.

Aleksei Olovjanisnikov (Medical Sciences BSc): Gap-junction communication and self-renewal in planaria

Gemma Hunt (Human Biology BSc ), Lina Motiti (Human Biology BSc), and Irene Di Lauro (Medical Sciences BSc): Targeting the LGR5 and beta-catenin pathways in neuroblastoma

Publications

Forgham H, Johnson D, Carter N, Veuger S and Carr-Wilkinson J (2015) Stem Cell Markers in Neuroblastoma — An Emerging Role for LGR5. Front. Cell Dev. Biol. 3:77.

Johnson DL, Jahoda CA, Reynolds NJ. Lysophospholipid signalling as a therapeutic target for human skin wound healing: role of GSK-3 beta/beta-catenin signalling. In: 44th Annual Meeting of the European Society for Dermatological Research. 2014, Copenhagen, Denmark: Nature Publishing Group.

Johnson D., Jahoda C.A.B., & Reynolds N. J. (2014) Lysophosphatidic acid-mediated signalling during human epidermal keratinocyte migration. British Journal of Dermatology 170(4).

Jans R., Mottram L., Johnson D., Brown A., Sikkink S., Ross K., & Reynolds N. J. (2013) Lysophosphatidic acid promotes cell migration through STIM1 and Orai1-mediated Ca2+ imobilisation and NFAT2 activation. Journal of Investigative Dermatology 133(3):793-802. Nature Publishing Group.

Memberships

Associate of the British Neuroscience Association (BNA)
National Centre for Universities and Business – Future Leader

Research

My interests mainly focus around the drivers of large scale tissue regeneration via stem cell signalling in response to tissue damage. In addition to seeking out the reparative signals that stem cells receive, I am also interested in the pathologies associated with this phenomenon including tissue degeneration and cancer biology.

Furthermore, I’m interested in producing a model of human substance withdrawal and addiction that will contribute to the understanding of neurological addictive disorders and reveal potential therapeutic targets.
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The Dugesia Lugubris species of planaria presents a simple model for translational investigations into large scale tissue regeneration and studies to investigate the molecular mechanisms of addiction and substance withdrawal

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Tracking of stem cells along a wound edge labelled with a specific immunofluorescent marker (image by Jacob Moorse)

Areas of Expertise

Neuroscience, cell biology, bioelectricity, regenerative medicine, pharmacology.

Twitter

https://twitter.com/DrDarrenJohnson

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