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Qualifications

BSc (Hons), PhD, FPVRI, FRSC, FACSM

About

My PhD thesis began during my appointment as the first Research Physiologist at the British Olympic Medical Centre (now the Olympic Medical Institute) in collaboration with the Department of Biochemistry at Oxford University (c/o Professor EA Newsholme and LM Castell). As a former International sportsman (football and athletics), my thesis focused on the factors that limit systemic oxygen transport and subsequent implications for human exercise performance.

Shortly thereafter, I was appointed Senior Lecturer at the University of Glamorgan where I developed the Hypoxia Research Laboratory focusing on the source, mechanisms and consequences of free radical formation in hypoxia with a specific interest in O2 delivery and how this impacts the human cerebral circulation. This laboratory is equipped with an environmental chamber that can simulate the high-altitude environment and state-of-the-art molecular techniques that include electron paramagnetic (EPR) spectroscopy and ozone-based chemiluminescence for the detection of reactive oxygen-nitrogen species. This has provided a complementary laboratory-based arm to a variety of field-based research expeditions conducted at terrestrial high-altitude (http://www.adinstruments.com/news/091208/University-of-Glamorgan-Takes-Neurovascular-Research——PowerLab—to-New-Heights/research/).

Following promotion to Reader, I worked with Professors RS Richardson and PD Wagner (University of California San Diego) to examine the basic mechanisms associated with free radical formation in human skeletal muscle. Using state-of-the-art techniques for the direct detection of free radicals and MRS-based measurement of intracellular PO2 in hypoxia, we identified that free radical “release” across the contracting skeletal muscle bed is inversely related to intracellular oxygenation and not simply due to increased (mitochondrial) electron flux. Similar approaches have been applied to measure free radical exchange across the hypoxic (and indeed exercising) human brain and lung during research sabbaticals spent at the University of Copenhagen, Denmark (c/o Professors BK Pedersen, K Moller and NH Secher) and University of Heidelberg, Germany (c/o Professor P Bärtsch). These experiments have provided unique insight into the basic mechanisms responsible for the oxidative-nitrosative-inflammatory stress typically encountered by different patient groups characterised by arterial hypoxaemia.

My current position is Professor of Physiology and Biochemistry at the University of South Wales where I am Research Unit Leader and Director of the (recently formed) Research Institute of Health & Wellbeing. My research group (Neurovascular Research Laboratory) is interested in how free radicals (for good or bad) impact upon the cerebral circulation across the spectrum of health and (mostly atherosclerotic) disease.

Experience

The Neurovascular Research laboratory houses state-of-the-art analytical techniques that range from the molecular to the morphological. We are interested in how exercise and hypoxia influence free radical-mediated vascular nitric oxide bioavailability (electron paramagnetic resonance spectroscopy and ozone chemiluminescence) and its impact on brain structure (diffusion-weighted MRI/MEG/EEG) and function (near infra-red spectroscopy, trans-cranial Doppler and Duplex ultrasonography). Several of these techniques have been acquired through externally-funded sabbaticals spent overseas and/or joint experimental collaborations that have facilitated long-standing published interactions with some of the most eminent specialists working within the oxygen transport, exercise and free radical biochemistry fields. This dynamic portfolio has allowed me to develop extensive research capabilities within a highly-established network and I have supervised 12 MPhil/PhD students with an additional 2 MPhil and 2 PhD students currently active. My current work is mentored by the pre-eminent Prof. JM McCord (University of Colorado Health Sciences Center, USA), twice nominated for the Nobel Prize for seminal contributions to free radical biology and medicine.

Below is a list of those collaborators considered “World-Leading” in their specialist fields:

Free radicals, inflammation and hemostasis
Profs S Pietri and M Culcasi, Équipe Sondes Moléculaires en Biologie et Stress Oxydant, Institut de Chimie
Radicalaire, Aix-Marseille Université, Marseille, France
Profs P Bärtsch, H Mäirbaurl and M Muckenthaler, Dept of Medicine, University of Heidelberg, Germany
Profs J McCord, L Berliner, S Eaton and G Eaton, Dept of Medicine/Dept of Chemistry and Biochemistry, University of Colorado Denver, USA
Profs PD Wagner, JB West and RS Richardson, Dept of Medicine, University of California San Diego, USA
Prof IS Young and J McEneny, Centre for Population and Health Sciences, Queen’s University, N.Ireland
Profs B Saltin, BK Pedersen, K Möller, C Lundby and NH Secher, Centre for Inflammation and Metabolism, The
Copenhagen Muscle Research Centre and Dept of Anaesthesia, University of Copenhagen, Denmark
Prof PA Evans, NISCHR Haemostasis Biomedical Research Unit, Morriston Hospital, Swansea, UK
Prof EA Newsholme and LM Castell, Dept of Biochemistry, University of Oxford, UK

Systemic vascular function
Profs C Sartori and U Scherrer, Dept of Internal Medicine and Botnar Center for Extreme Medicine, University
Hospital Lausanne, Switzerland in collaboration with the Bolivian Institute of High Altitude Biology
Prof JH Halcox, Wales Heart Research Institute, Cardiff University
Prof RS Richardson, Depts of Medicine and Exercise and Sport Science, University of Utah and Geriatric Research,
Education and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, Utah, USA

Brain structure and function
Prof D Janigro and N Marchi, Dept of Cell Biology, Cleveland Clinic Foundation, USA
Profs RG Wise, D Jones, K Graham and A Lawrence, Cardiff University Brain Research Imaging Centre, Cardiff University, UK
Prof S Ogoh, Dept of Biomedical Engineering, Toyo University, Japan
Prof A Rosser, Drs M Busse & L Quinn, School of Biosciences & Healthcare Sciences, Cardiff University
Prof PB Raven, Dept of Integrative Physiology, University of North Texas Health Science Center, USA
Prof RB Panerai, Dept of Medical Physics, University of Leicester, UK
Dr WN Colier, Dept of Geriatric Medicine, Radboud University, The Netherlands
Prof PN Ainslie, School of Health and Exercise Sciences, University of British Columbia, Canada
Prof CH Imray, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
Prof F Keleştemur, Department of Neurosurgery, University of Istanbul, Turkey
Prof Z Dujic, School of Medicine, University of Split, Split, Croatia
Profs B Cantu and A McKee, Center for the Study of Traumatic Encephalopathy, Department of Neurology, Boston University, Massachusetts, USA

Surgery
Prof A van Rij, Dept of Surgical Sciences, University of Otago, New Zealand
Profs MH Lewis and I Williams, Dept of Surgery, Royal Glamorgan Hospital/Cardiff University, UK

Comparative physiology
Prof MA Fedak, Scottish Oceans Institute, University of St Andrews, UK
Prof P Friend, Dept of Surgery, University of Oxford, UK

Responsibilities

My current position involves three functionally integrated academic roles:

1. Professor of Physiology and Biochemistry
This position involves undergraduate/postgraduate teaching/supervision and leading the Neurovascular Research Laboratory.

2. Director of the Research Institute of Health & Wellbeing
I provide leadership to members of the Research Institute to ensure that research is of the highest standard in terms of originality, significance and rigor, a role that involves the following duties:
i. Development and implementation of a Research Vision, Mission, Strategy and Business Plan
ii. Development and implementation of “aligned research themes” that have the potential to be internationally excellent
iii. Enhancement of external research funding through grant income and commercial sources with a view to ensuring financial sustainability
iv. Optimisation of the University’s reputation in research including performance in any future assessment of research excellence
v. Appraisal of members and setting of strategic targets

3. Research Unit Leader
I am also responsible for leading my group’s Unit of Assessment submission to the UK-based Research Excellence Framework (REF 2020) designed to assess the quality of research conducted in publicly funded Higher Education Institutions (http://www.ref.ac.uk/). I previously led our submission to REF 2014, Research Assessment Exercise (RAE) in 2008 having assisted with the RAE 2001 submission.

These duties involve senior management roles requiring regular interaction with the Deputy Vice Chancellor for Research to whom I report directly for all research-related activities. I regularly engage in senior research training events and preside on various academic committees including the Professoriate, Human Research Ethics, Research Unit Leaders, Faculty Research Operational Group and Research and Scholarly Committees.

Publications

2017:
Bailey, D.M., Rasmussen, P., Overgaard, M., Evans, K.A., Bohm, A.M., Seifert, T., Brassard, P., Zaar, M., Nielsen, H.B., Raven, P.B. and Secher, N.H. (2017). Nitrite and S-nitrosohemoglobin exchange across the human cerebral and femoral circulation: relationship to basal and exercise blood flow responses to hypoxia.
Circulation 135: 166-176.

Imhoff, S., Malenfant, S., Nadreau, E., Poirier, P., Bailey, D.M. and Brassard, P. (2017). Uncoupling between cerebral perfusion and oxygenation during incremental exercise in an athlete with postconcussion syndrome: a case report.
Physiological Reports Jan;5(2). pii: e13131. doi: 10.14814/phy2.13131.

Bailey, D.M. (2017). From Monro and Kellie to mountains and concussion; the science of slosh.
Journal of Applied Physiology Jan 1;122(1):218-220. doi: 10.1152/japplphysiol.01022.2016.

Stacey, B.S., Smith, J.A., Owens, T.S. and Bailey, D.M. (2017). All’s swell with the brain; on the significance of blood-brain barrier disruption in hypoxia.
Journal of Applied Physiology Jan 1;122(1):218-220. doi: 10.1152/japplphysiol.01022.2016.

Bain, A.R., Ainslie, P.N., Barak, O.F., Hoiland, R.L., Drvis, I., Mijacika, T., Bailey, D.M., Santoro, A., deMasi, D.K., Dujic, Z. and MacLeod, D.B. (2017).
Journal of Cerebral Blood Flow and Metabolism Jan 1:271678X16686093. doi: 10.1177/0271678X16686093.

Bailey, D.M. (2017). On the significance of altered drug pharmacokinetics-pharmacodynamics at high altitude.
High Altitude Medicine and Biology Jan 3. doi: 10.1089/ham.2016.0128.

Ogoh, S., Sørensen, H., Hirasawa, A., Sasaki, H., Washio, T., Hashimoto, T., Bailey, D.M. and Secher, N.H. Effect of alpha-1 blockade on external carotid artery blood flow during acute hypotension and its contribution towards cerebral blood flow regulation in man.
Physiological Reports (accepted-in-the-press).

Dahl, R.H., Berg, R.M.G., Taudorf, S., Bailey, D.M., Lundby, C., Larsen, F.S., Pedersen, B.K. and Möller, K. A critical reassessment of the blood-brain barrier transport of large neutral amino acids during acute systemic inflammation in humans.
Metabolic Brain Disease (accepted-in-the-press).

2016:
Bailey, D.M., Willie, C.K., Hoiland, R.L., Bain, A.R., MacLeod, D.B., Santoro, M.A., DeMasi, D.K., Andrijanic, A., Mijacika, T., Barak, O.F., Dujic, Z. and Ainslie, P.N. Surviving without oxygen; how low can the human brain go?
High Altitude Medicine and Biology (accepted-in-the-press): doi not currently issued.

Bailey, D.M. (2016). The brain in hypoxia; curiosity, cause and consequence.
Experimental Physiology 101: 1157-1159

Bailey, D.M. (2016). Studying dementia from atop Mount Everest.
Science doi: 10.1126/science.aaf9844 (interview c/o P. Monahan)

Bailey, D.M. (2016). Medical complications cut Everest research expedition short.
Science doi: 10.1126/science.aaf5724 (interview c/o P. Monahan).

Claassen, J.A., Meel-van den Abeelen, A.S., Simpson, D.M., Panerai, R.B.and international Cerebral Autoregulation Research Network (CARNet) (2016). Transfer function analysis of dynamic cerebral autoregulation: A white paper from the International Cerebral Autoregulation Research Network.
Journal of Cerebral Blood Flow and Metabolism 36: 665-80

Bailey, D.M., Evans, T.G., Thomas, K.G., White, R.D., Twine, C.P., Lewis, M.H. and Williams, I.M. (2016). Intervisceral artery origins in patients with abdominal aortic aneurysmal disease; evidence for systemic vascular remodelling.
Experimental Physiology (accepted-in-the-press): doi: 10.1113/EP085804.

Ainslie, P.N., Hoiland, R.L. and Bailey, D.M. (2016). Lessons from the laboratory; integrated regulation of cerebral blood flow during hypoxia.
Experimental Physiology (accepted-in-the-press): doi: 10.1113/EP085671.

Paquette, M., LeBlanc, O., Lucas, S.J., Thibault, G., Bailey, D.M. and Brassard, P. (2016). Effects of submaximal and supramaximal interval training on determinants of endurance performance in endurance athletes.
Scandinavian Journal of Medicine and Science in Sports (accepted-in-the-press): doi: 10.1111/sms.12660.

Bain, A.R., Ainslie, P.N., Hoiland, R.L., Barak, O.F., Cavar, M., Drvis, I., Stembridge, M., MacLeod, D.M., Bailey, D.M., Dujic, Z. and MacLeod, D.B. (2016). Cerebral oxidative metabolism is decreased with extreme apnea in humans; impact of hypercapnia.
Journal of Physiology (accepted-in-the-press) doi: 10.1113/JP272404.

Ogoh, S., Sorensen, H., Hirasawa, A, Sasaki, H., Washio, T., Hashimoto, T., Bailey, D.M. and Secher, N.H. (2016). Dynamic cerebral autoregulation is unrelated to decrease in external carotid artery blood flow during acute hypotension in healthy young men.
Experimental Physiology (accepted-in-the-press) doi: 10.1113/EP085772.

Burley, C.V., Bailey, D.M., Marley, C.J. and Lucas, S.J. (2016). Brain train to combat brain drain; focus on exercise strategies that optimise neuroprotection
Experimental Physiology (accepted-in-the-press): online, doi not currently issued.

Davies, N.A., Llywyd, O., Brugniaux, J.V., Davies, G.R., Lawrence, M.J., D’Silva, L.A., Morris, R.H.K., Hawkins, K., Williams, P.R., Bailey, D.M. and Evans, P.A. Effects of exercise intensity on clot microstructure and mechanical properties in healthy individuals
Thrombosis Research (accepted-in-the-press) doi: 10.1016/j.thromres.2016.05.018.

Hirasawa, A., Sato, K., Yoneya, M., Sadamato, T., Bailey, D.M. and Ogoh, S. (2016). Heterogeneous regulation of brain blood flow during low-intensity resistance exercise.
Medicine and Science in Sport and Exercise (accepted-in-the-press): online, doi not currently issued.

Ogoh, S., Sørensen, H., Hirasawa, A., Sasaki, H., Washio, T., Hashimoto, T., Bailey, D.M. and Secher, N.H. Effect of alpha-1 blockade on external carotid artery blood flow during acute hypotension and its contribution towards cerebral blood flow regulation in man.
Physiological Reports (accepted-in-the-press): online, doi not currently issued.

Hoiland, R.L., Bain, A.R., Rieger, M., Bailey, D.M. and Ainslie, P.N. (2016). Hypoxemia, oxygen content, and the regulation of cerebral blood flow.
American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) 310: R398-413.

2015:
Berg, R.M., Plovsing, R.R., Bailey, D.M., Holstein-Rathlou, N.H., Möller, K. (2015). The dynamic cerebral autoregulation to induced blood pressure changes in human experimental and clinical sepsis.
Clinical Physiology and Functional Imaging 42: 740-746.

Berg, R.M., Plovsing, R.R., Bailey, D.M., Holstein-Rathlou, N.H., Möller, K. (2015). The dynamic cerebral autoregulatory adaptive response to noradrenaline is attenuated during systemic inflammation in humans.
Clinical and Experimental Pharmacology and Physiology 42: 740-746.

Rimoldi, S.F., Sartori, C., Rexhaj, E. Bailey, D.M., Marchi, S.F., McEneny, J., Arx, R.V., Cerny, D., Duplain, H., Germond, M., Allemann, Y. and Scherrer, U. (2015). Antioxidants improve vascular function in children conceived by assisted reproductive technologies: A randomized double-blind placebo-controlled trial.
European Journal of Preventative Cardiology 11: 1399-1407.

Fall, L., New, K.J., Evans, K.A. and Bailey, D.M. (2015). Arterial hypoxaemia and its impact on coagulation: significance of altered redox homeostasis.
Journal of Clinical Pathology 68: 752-754.

Lucas, S.J.E., Cotter, J.D., Brassard, P. and Bailey, D.M. (2015). High intensity exercise and cerebrovascular health; curiosity, cause and consequence.
Journal of Cerebral Blood Flow and Metabolism 35: 902-911.

2014:
Woodside, J.S., Gutowski, M., Fall, L., James, P.E., McEneny, J., Young, I.S., Ogoh, S. and Bailey, D.M. (2014). Systemic oxidative-nitrosative-inflammatory stress during acute exercise in hypoxia; implications for microvascular oxygenation and aerobic capacity.
Experimental Physiology 99: 1648-1662.

Brugniaux, J.V., Marley, C.J., Hodson, D., New, K.J. and Bailey, D.M. (2014). Acute exercise stress reveals cerebrovascular benefits associated with moderate gains in cardiorespiratory fitness.
Journal of Cerebral Blood Flow and Metabolism 34: 1873-1876.

Bailey, D.M., Lundby, C., Berg, R.M., Taudorf, S., Rahmouni, H., Gutowski, M., Mulholland, C.W., Sullivan, J.L., Swenson, E.R., McEneny, J., Young, I.S., Pedersen, B.K., Møller, K., Pietri, S. and Culcasi, M. (2014). On the antioxidant properties of erythropoietin and its association with the oxidative-nitrosative stress response to hypoxia in humans.
Acta Physiological Scandinavica 212: 175-187

Miyamoto, T., Bailey, D.M., Nakahara, H., Ueda, S., Inagaki, M. and Ogoh, S. (2014). Manipulation of central blood volume and implications for respiratory control function.
American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) 306: H1669-H1678.

Ogoh, S., Lericollais, R., Hirasawa, A., Sakai, S., Normand, H. and Bailey, D.M. (2014). Regional redistribution of blood flow in the external and internal carotid arteries during acute hypotension.
American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) 306: R747-R751.

Appleton, N.D., Bailey, D.M., Morris-Stiff, G. and Lewis, M.H. (2014). Neutrophil to lymphocyte ratio predicts perioperative mortality following open elective repair of abdominal aortic aneurysms.
Vascular and Endovascular Surgery 48: 311-316.

Lewis, N.C.S., Bailey, D.M., duManoir, G., Messinger, L., Lucas, S.J.E., Cotter, J.D., Donnelly, J., McEneny, J., Young, I.S., Stembridge, M., Burgess, K.R., Basnet, A.S. and Ainslie, P.N. (2014). Conduit artery structure and function in lowlanders and native highlanders: relationships with oxidative stress and role of sympathoexcitation.
Journal of Physiology 592: 1009-1024.

Imray, C.H.E., Chan, C.W.M., Stubbings, A., Rhodes, H., Patey, S., Wilson, M., Bailey, D.M., and Wright, A.D. for the Birmingham Medical Research Expeditionary Society. (2014). Time course variations in the mechanisms by which cerebral oxygen delivery is maintained on exposure to hypoxia/altitude
High Altitude Medicine and Biology 15: 21-27.

Bailey, D.M., Rimoldi, S.F., Allemann, Y., Sartori, C. and Scherrer, U. (2014). Cobalt chelation and free radical-mediated vascular endothelial dysfunction in chronic mountain sickness.
Chest 145: 423-424.

2013:
Pratali, L., Allemann, Y., Rimoldi, S.F., Faita, F., Hutter, D., Rexhaj, E., Brenner, R., Bailey, D.M., Sartori, C., Salmon, C.S., Villena, M., Scherrer, U., Picano, E. and Sicari, R. (2013). RV contractility and exercise-induced pulmonary hypertension in chronic mountain sickness: a stress echocardiographic and tissue doppler imaging study.
Journal of the American College of Cardiology-Cardiovascular Imaging 6: 1287-1297.

Morris-Stiff, G., Teli, M., Khan, P.Y., Ogunbiyi, S.O., Champ, C.S., Hibberd, R., Brown, R. Bailey, D.M., Winter, R.K. and Lewis, M.H. (2013). Internal carotid artery occlusion: its natural history including recanalization and subsequent neurological events.
Vascular and Endovascular Surgery 47: 603-607

Bailey, D.M., Marley, C. J., Brugniaux, J.V., Hodson, D., New, K.J., Ogoh, S. and Ainslie, P.N. (2013). Elevated aerobic fitness sustained throughout the adult lifespan is associated with improved cerebral hemodynamics.
Stroke 44: 3235-3238.

Berg, R.M., Plovsing, R.R., Evans, K.A., Christiansen, C.B., Bailey, D.M., Holstein-Rathlou, N.H. and Möller. (2013). Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers.
Critical Care 17: R238

Bailey, D.M., Rimoldi, S.F., Rexhaj, E., Pratali, L., Salmòn, C.S., Vilena, M., McEneny, J., Young, I.S., Nicod, P., Allemann, Y., Scherrer, U. and Sartori, C. (2013). Oxidative-nitrosative stress and systemic vascular function in highlanders with and without exaggerated hypoxemia
Chest 143: 444-451.

Bailey, D.M., Jones, D.W., Sinnott, A., Brugniaux, J.V., New, K.J., Hodson, D., Marley, C.J., Smirl, J.D. and Ainslie, P.N. (2013). Impaired cerebral hemodynamic function in professional boxers.
Clinical Science 124: 177-189.

Ainslie, P.N. and Bailey, D.M. (2013). Your ageing brain: the lows and highs of cerebral metabolism.
Journal of Physiology 591: 1591-1592.

Ogoh, S., Nakahara, H., Okazaki, K., Bailey, D.M. and Miyamoto, T. (2013). Cerebral hypoperfusion modifies the respiratory chemoreflex during orthostatic stress.
Clinical Science 125: 37-44.

Fall, L. and Bailey, D.M. (2013). Interpretive limitations associated with plasma volume shifts in the clinical assessment of hemostasis.
Psychosomatic Medicine. 75:222-223.

New, K.J., Reilly, M.E., Templeton, K., Ellis, G., James, P.E., McEneny, J., Penney, M., Hooper, J., Hullin, D., Davies, B. and Bailey, D.M. (2013). Free radical-mediated lipid peroxidation and systemic nitric oxide bioavailability: implications for post-exercise hemodynamics.
American Journal of Hypertension. 26: 126-134.

Harris, A.D., Roberton, V.H., Huckle, D.L., Saxena, N., Evans, C.J., Murphy, K., Hall, J.E., Bailey, D.M., Mitsis, G., Edden, R.A. and Wise, R.G. (2013). Temporal dynamics of lactate concentration in the human brain during acute inspiratory hypoxia.
Journal of Magnetic Resonance Imaging 37: 739-745.

2012:
Berg, R.M., Plovsing, R.R., Ronit, A., Bailey, D.M., Holstein-Rathlou, N.H. and Møller, K. (2012). Disassociation of static and dynamic cerebral autoregulatory performance in healthy volunteers after lipopolysaccharide infusion and in patients with sepsis.
American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) 303: R1127-R1135.

Davison, G.W., Ashton, T., McEneny, J., Young, I.S., Davies, B. and Bailey, D.M. (2012). Critical difference applied to exercise-induced oxidative stress: the dilemma of distinguishing biological from statistical change.
Journal of Physiology and Biochemistry 68: 377-384.

Bailey, D.M., Brugniaux, J.V., Pietri, S., Culcasi, M. and Swenson, E.R. (2012). Redox regulation of neurovascular function by acetazolamide: complementary insight into mechanisms underlying high-altitude acclimatisation.
Journal of Physiology 590: 3627-3628.

Berg, R.M., Taudorf, S., Bailey, D.M., Lundby, C., Larsen, F.S., Pedersen, B.K. and Møller, K. (2012). Effects of lipopolysaccharide infusion on arterial levels and transcerebral exchange kinetics of glutamate and glycine in healthy humans.
Acta Pathologica, Microbiologica, et Immunologica Scandinavica 120: 761-766.

Geinas, J.C., Marsden, K.R., Tzeng, Y.C., Smirl, J.D., Smith, K.J., Willie, C.K., Lewis, N.C., Binsted, G., Bailey, D.M., Bakker, A., Day, T.A. and Ainslie, P.N. (2012). Influence of posture on the regulation of cerebral perfusion.
Aviation, Space and Environmental Medicine 83: 751-757.

Rimoldi, S.F., Rexhaj, E., Pratali, L., Bailey, D.M., Hutter, D., Faita, F., Salinas Salmòn, C, Villena, M., Nicod, P., Allemann, Y., Scherrer, U. and Sartori, C. (2012). Systemic vascular dysfunction in patients with chronic mountain sickness.
Chest 141: 139-146

Rasmussen, P., Taudorf, S., Bailey, D.M., Olsen, N.V., Møller, K. and Lundby, C. (2012). Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans.
FASEB Journal 26: 1831-1834.

Miyazawa, T., Horiuchi, M., Ichikawa, D., Sato, K., Tanaka, N., Bailey, D.M. and Ogoh, S. (2012). Kinetics of exercise-induced neural activation; interpretive dilemma of altered cerebral perfusion.
Experimental Physiology 97: 219-227, 2012

Marsden, K.R., Haykowsky, M.J., Smirl, J.D., Jones, H., Nelson, M.D., Altamirano-Diaz, L.A., Gelinas, J.C., Tzeng, Y.C., Smith, K.J., Willie, C.K., Bailey, D.M. and Ainslie, P.N. (2012). Aging blunts hyperventilation-induced hypocapnia and reduction in cerebral blood flow velocity during maximal exercise.
Age 34: 725-735.

2011:
Cochand, N.J., Wild, M., Brugniaux, J.V., Davies, P.J., Evans, K.A., Wise, R.G. and Bailey, D.M. (2011). Sea-level assessment of dynamic cerebral autoregulation predicts susceptibility to acute mountain sickness at high-altitude.
Stroke 42: 3628-3630

Bailey, D.M., Evans, KA, McEneny, J., Young, I.S., Hullin, D.A., James, P.E., Ogoh, S., Ainslie, P.N., Lucchesi, C., Rockenbauer, A., Culcasi, M. and Pietri, S. (2011). Exercise-induced oxidative-nitrosative stress is associated with impaired dynamic cerebral autoregulation and blood-brain barrier leakage.
Experimental Physiology 96: 1196-1207. Highlighted Paper (top 2%)

Berg, R.M., Møller, K. and Bailey, D.M. (2011). Neuro-oxidative-nitrosative stress in sepsis
Journal of Cerebral Blood Flow and Metabolism 31: 1532-1544.

Berger, M.M., Luks, A.M., Bailey, D.M., Menold, E., Robotti, G.C., Mairbäurl, H., Dehnert, C., Swenson, E.R. and Bärtsch, P. (2011). Trans-pulmonary plasma catecholamines in acute high-altitude pulmonary hypertension.
Journal of Wilderness Medicine 22: 37-45

Bailey, D.M., Taudorf, S., Berg, R.M., Lundby, C., Pedersen, B.K., Rasmussen, P. and Møller, K. (2011). Cerebral formation of free radicals during hypoxia does not cause structural damage and is associated with a reduction in mitochondrial PO2; evidence of O2-sensing in humans?
Journal of Cerebral Blood Flow and Metabolism 31: 1020-1026.
Highlighted Paper

Willie, C.K., Colino, F.L., Bailey, D.M., Tzeng, Y.C., Binsted, G., Jones, L.W., Haykowsky, M.J., Bellapart, J., Ogoh, S., Smith, K.J., Smirl, J.D., Day, T.A., Lucas, S.J., Eller, L.K. and Ainslie, P.N. (2011). Utility of transcranial doppler ultrasound for the integrative assessment of cerebrovascular function.
Journal of Neuroscience Methods 196; 221-237.

Wray, D.W., Nishiyama, S.K., Donato, A.J., Carlier, P., Bailey, D.M., Uberoi, A. and Richardson, R.S. (2011). The paradox of oxidative stress and exercise with advancing age.
Exercise Sport Science Reviews 39: 68-76

Berg, R.M.G., Taudorf, S., Bailey, D.M., Lundby, C., Larsen, F.S., Pedersen, B.K. and Møller, K. (2011). Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans.
Critical Care 14: R16-R23.

Bailey, D.M., Dehnert, C., Luks, A., Menold, E., Castell, C., Schendler, G., Faoro, V., Gutowski, M., Evans, K., Taudorf, S., James, P., McEneny, J., Young, I.S., Swenson, E., Mairbäurl, H., Bärtsch, P. and Berger, M.M. High-altitude pulmonary hypertension is associated with a free radical-mediated reduction in pulmonary nitric oxide bioavailability. (2011).
Journal of Physiology 588: 4837-4847
Highlighted Paper

Fall, L., Evans, K.A., Lewis, M.H. and Bailey, D.M. (2011). Haemostatic response to hypoxaemic-exercise stress: the dilemma of plasma volume correction.
Journal of Clinical Pathology 64: 269-271

Fogarty, M.C., Hughes, C.M., Burke, G., Brown, J.C., Trinick, T.R., Duly, E., Bailey, D.M. and Davison, G.W. (2011). Exercise-induced lipid peroxidation: implications for deoxyribonucleic acid (DNA) damage and systemic free radical production.
Environmental and Molecular Mutagenesis 52: 35-42

Faoro, V., Fink, B., Taudorf, S., Dehnert, C., Berger, M.M., Swenson, E.R., Bailey, D.M., Bärtsch, P. and Mairbäurl, H. (2011). Acute in-vitro hypoxia and high altitude (4559m) exposure decreases leukocyte oxygen consumption.
American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) 300: R32-R39

2010:
Bailey, D.M. (2010). Impaired cerebral autoregulation in acute mountain sickness; incidental yet adaptive?
Stroke 41:e571

Bailey, D.M., McEneny, J., Mathieu-Costello, O., Henry, R.R., James, P.E., McCord, J.M., Pietri, S., Young, I.S. and Richardson, R.S. (2010). Sedentary aging increases resting and exercise-induced intramuscular free radical formation
Journal of Applied Physiology 109: 449-456.

Bailey, D.M. (2010). Redox-regulation of post-prandial vascular endothelial dysfunction; prophylactic benefits of high-intensity exercise.
Journal of the American College of Cardiology 55: 258.

Bailey, D.M., Bärtsch, P., Knauth, M. and Baumgartner, R.W. (2010). Emerging concepts in acute mountain sickness and high-altitude cerebral edema; from the molecular to the morphological.
Journal of Cellular and Molecular Life Sciences 66: 3583-3594.

Sullivan, J.L., Bailey, D.M. and Zacharski, L.R. (2010). Altitude, iron and cardiovascular mortality.
Circulation 13: e376.

Ingram, T.E., Pinder, A.G., Bailey, D.M., Fraser, A.G. and James, P.E. (2010). Low-dose sodium nitrite vasodilates hypoxic human pulmonary vasculature by a means that is not dependent on a simultaneous elevation in plasma nitrite.
American Journal of Physiology (Heart and Circulatory Physiology) 298: H331-H339.

Donato, A.J., Uberoi, A., Bailey, D.M., Wray, D.W. and Richardson, R.S. (2010). Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men.
American Journal of Physiology (Heart and Circulatory Physiology) 298: H671-H678.

Edden, R.A.E., Harris, A.D., Murphy, K., Evans, C.J., Saxena, N., Hall, J.E., Bailey, D.M. and Wise, R.G. (2010). Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia
Journal of Magnetic Resonance Imaging 32: 320-325.

Dehnert., C, Luks, A.M., Schendler, G., Menold, E., Berger, M.M., Mairbäurl, H., Faoro, V., Bailey, D.M., Castell, C., Hahn, G., Vock, P., Swenson, E.R. and Bärtsch, P. (2010). No evidence for interstitial lung oedema by extensive pulmonary function testing at 4559 m.
European Respiratory Journal 35: 812-820.

2009:
Bailey, D.M., Taudorf, S., Berg, R.M.G., Lundby, C., McEneny, J., Young, I.S., Evans, K.A., James, P.E., Shore, A., Hullin, D.A., McCord, J.M., Pedersen, B.K. and Møller, K. (2009). Increased cerebral output of free radicals during hypoxia: implications for acute mountain sickness?
American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) 297: R1283-R1292.

Bailey, D.M., Taudorf, S., Berg, R.M.G., Jensen, L.T., Lundby, C., Evans, K.A., James, P.E., Pedersen, B.K. and Møller, K.
(2009). Trans-cerebral exchange kinetics of nitrite and calcitonin gene-related peptide in acute mountain sickness: evidence against trigeminovascular activation?
Stroke 40: 2205-2208.

Bailey, D.M., Evans, K.A., James, P.E., McEneny, J., Young, I.S., Kewley, E., Fall, L., McCord, J.M., Møller, K. and Ainslie, P.N. (2009). Altered free radical metabolism in acute mountain sickness: implications for dynamic cerebral autoregulation and blood-brain barrier function.
Journal of Physiology 15: 73-85.
Highlighted Paper

Bailey, D.M., George, W.O. and Gutowski, M. (2009). Theoretical studies of L-ascorbic acid (vitamin C) and selected oxidised, anionic and free-radical forms.
Journal of Molecular Structure: THEOCHEM 910: 61-68.

Berger, M.M., Dehnert, C., Bailey, D.M., Luks, A.M., Menold, E., Castell, C., Schendler, G., Faoro, V., Mairbäurl, H., Bärtsch, P. and Swenson, E.R. (2009). Transpulmonary plasma ET-1 and nitrite differences in high altitude pulmonary hypertension.
High Altitude Medicine and Biology 10: 17-24.

Harris, R.A., Nishiyama, S.K., Wray, D.W., Tedjasaputra, V., Bailey, D.M. and Richardson, R.S. (2009). The effect of oral antioxidants on brachial artery flow-mediated dilation following 5 and 10 min of ischemia.
European Journal of Applied Physiology and Occupational Physiology 107: 445-453.

Irwin, D., McCord, J., Nozik-Grayck, E., Becky, G., Foreman, B., Sullivan, T., White, M., Crossno, J., Bailey, D.M., Flores, S., Majka, S., Klemm, D. and Tissot van Patot, M. (2009). A potential role for reactive oxygen species and the HIF-1α-VEGF pathway in hypoxia-induced pulmonary vascular leak.
Free Radical Biology and Medicine 47: 55-61.

Taudorf, S., Berg, R.M., Bailey, D.M. and Møller, K. (2009). Cerebral blood flow and oxygen metabolism measured with the Kety-Schmidt method using nitrous oxide.
Acta Anaesthesiologica Scandinavica 53: 159-167.

Wray, D.W., Uberoi, A., Lawrenson, L., Bailey, D.M. and Richardson, R.S. (2009). Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome.
Clinical Science 116: 433-441.

2008:
Davison, G.W., Ashton, T., George, L., Young, I.S., McEneny, J., Davies, B., Jackson, S.K., Peters, J.R. and Bailey, D.M. (2008). Molecular detection of exercise-induced free radicals following ascorbate prophylaxis in Type I Diabetes Mellitus: a randomised controlled trial.
Diabetalogia 51: 2049-2059

Davison, G.W., Ashton, T.A., Davies, B. and Bailey, D.M. (2008). In-vitro electron paramagnetic resonance characterization of free radicals: Relevance to exercise-induced lipid peroxidation and implications of ascorbate prophylaxis.
Free Radical Research 42: 379-386.

Kallenberg, K., Dehnert, C., Dörfler, A., Schellinger, P., Bailey, D.M., Knauth, M. and Bärtsch, P. (2008). Microhemorrhages in non-fatal high altitude cerebral edema.
Journal of Cerebral Blood Flow and Metabolism 28: 1635-1642

2007:
Bailey, D.M., Morris-Stiff, G., McCord, J.M. and Lewis, M.H. (2007). Has free radical release across the brain following carotid endarterectomy traditionally been under-estimated? Significance of reperfusion hemodynamics.
Stroke 38: 1946-1948.

Bailey, D.M., Lawrenson, L., McEneny, J., Young, I.S., James, P.E., Jackson, S.K., Henry, R., Mathieu-Costello, O. and Richardson, R.S. (2007). Direct evidence for exercise-induced free radical accumulation in human skeletal muscle.
Free Radical Research 41: 182-190.

Bailey, D.M., Kallenberg, K., Christ, S., Mohr, A., Roukens, R., Menold, E., Steiner, T., Bärtsch, P. and Knauth, M. (2007). Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness.
Journal of Cerebral Blood Flow and Metabolism 27: 1064-1071.

Richardson, R.S., Donato, A.J., Uberoi, A., Wray, D.W., Lawrenson, L., Nishiyama, S. and Bailey, D.M. (2007). Exercise-induced brachial artery vasodilation: role of free radicals.
American Journal of Physiology (Heart and Circulatory Physiology) 292: H1516-H1522.

Barden, J., Lawrenson, L., Poole, J.G., Wray, D.W., Kim, J., Bailey, D.M., and Richardson, R.S. (2007). Limitations to vasodilatory capacity and VO2max in trained human skeletal muscle.
American Journal of Physiology (Heart and Circulatory Physiology) 292: H2491-H2497.

2006:
Bailey, D.M., Robach, P., Thomsen, J.J. and Lundby, C. (2006). Erythropoietin depletes iron stores: antioxidant neuroprotection for ischemic stroke?
Stroke 37: 2453.

Bailey, D.M., Sudarsanamn, R., McEneny, J., Young, I.S., Hullin, D.A., Davies, B., McKeeman, G., McCord, J.M. and Lewis, M.H. (2006). Vitamin C prophylaxis promotes oxidative lipid damage during surgical ischemia-reperfusion.
Free Radical Biology and Medicine 40: 591-600.

Bailey, D.M., Roukens, R., Knauth, M., Kallenberg, K., Christ, S., Mohr, A., Genius, J., Storch-Hagenlocher, B., Meisel, F., McEneny, J., Young, I.S., Steiner, T. and Bärtsch, P. (2006). Free radical-mediated damage to barrier function is not associated with altered brain morphology in high-altitude headache.
Journal of Cerebral Blood Flow and Metabolism 26:99-111.

Davison, G.W., Morgan, R.M., Davies, B., Hiscock, N., Boisseau, N., Castell, L.M. and Bailey, D.M. (2006). Manipulation of systemic oxygen flux by acute exercise and normobaric hypoxia: implications for reactive oxygen species generation.
Clinical Science 110:133-41.

Baker, J.S., Morgan, R., Hullin, D., Castell, L.M., Bailey, D.M. and Davies, B. (2006). Changes in blood markers of serotoninergic activity following high intensity cycle ergometer exercise.
Research in Sports Medicine 14:191-203.

New, K., Bailey, D.M. and Campbell, I. (2006). Extremes of barometric pressure.
Anaesthesia and Intensive Care Medicine 6: 376-379.

2005:
Bailey, D.M. (2005). Supplemental ascorbate and exercise-induced IL-6 metabolism; focus on Fenton chemistry and redox-regulation of vascular homeostasis.
European Journal of Applied Physiology and Occupational Physiology 94: 487-489.

2004:
Bailey, D.M., Young, I.S., McEneny, J., Lawrenson, L., Kim, J., Barden, J. and Richardson, R.S. (2004). Regulation of free radical outflow from an isolated muscle bed in exercising humans.
American Journal of Physiology (Heart and Circulatory Physiology) 287: H1689-H1699.

Bailey, D.M., Kleger, G.-R., Holzgraefe, M., Ballmer, P. and Bärtsch, P. (2004). Pathophysiological significance of peroxidative stress, neuronal damage and membrane permeability in acute mountain sickness.
Journal of Applied Physiology 96: 1459-1463.

Bailey, D.M., Davies, B., Young, I.S., Jackson, M.J., Davison, G.W., Isaacson, R. and Richardson, R.S. (2004). EPR spectroscopic evidence of free radical outflow from an isolated muscle bed in exercising humans; functional significance of decreasing intracellular PO2 vs. increasing O2 flux.
Advances in Experimental Medicine and Biology 540: 297-303.

Bailey, D.M., Ainslie, P.N., Jackson, S.K., Richardson, R.S. and Ghatei, M. (2004). Evidence against redox regulation of energy homeostasis in humans at high-altitude.
Clinical Science 107: 1-12.

Bailey, D.M. (2004). Ascorbate, blood-brain barrier function and acute mountain sickness: a radical hypothesis.
Wilderness and Environmental Medicine 15:231-233.

Pullin, C.H., Bellamy, M.F., Bailey, D.M., Ashton, M., Davies, B., Williams, S., Goodfellow, J., Wilson, J.F. and Lewis, M.J. (2004). Time course of changes in endothelial function following exercise in habitually sedentary men.
Journal of Exercise Physiology 7: 14-22.

Bärtsch, P., Bailey, D.M., Berger, M.M., Knauth, M. and Baumgartner, R.W. (2004). Acute mountain sickness; controversies, advances and future directions.
High Altitude Medicine and Biology 5: 110-124.

Baker, J.S., Bailey, D.M., Hullin, D., Young, I. and Davies, B. (2004). Metabolic implications of resistive force selection for oxidative stress and markers of muscle damage during 30 s of high-intensity exercise.
European Journal of Applied Physiology and Occupational Physiology 92: 321-327.

2003:
Bailey, D.M., Davies, B., Young, I.S., Jackson, M.J., Davison, G.W., Isaacson, R. and Richardson, R.S. (2003). EPR spectroscopic detection of free radical outflow from an isolated muscle bed in exercising humans.
Journal of Applied Physiology 94: 1714-1718.

Bailey, D.M., Davies, B., Castell, L.M., Collier, D.J., Milledge, J.S., Hullin, D.A., Seddon, P.S. and Young, I.S. (2003). Symptoms of infection and acute mountain sickness; associated metabolic sequelae and problems in differential diagnosis.
High Altitude Medicine and Biology 4:319-333.

Bailey, D.M., Bärtsch, P. and Cooper, M.A. (2003). Electron paramagnetic resonance spectroscopic evidence of increased free radical generation and selective damage to skeletal muscle following lightning injury.
High Altitude Medicine and Biology 4: 281-291.

Bailey, D.M. (2003). Radical dioxygen; from gas to (unpaired!) electrons.
Advances in Experimental Medicine and Biology 543: 201-221.

Baker, J.S., Bailey, D.M., Dutton, J. and Davies, B. (2003). Catecholamine responses to high intensity cycle ergometer exercise: Body mass or composition?
Journal of Physiology and Biochemistry 59: 77-83.

2002:
New, K., Bailey, D.M. and Campbell, I. (2002). Barometric pressure; extremes and challenges.
Anaesthesia and Intensive Care Medicine 3: 392-396.

Davison G.W., George, L., Jackson, S.K., Young, I.S., Davies, B., Bailey, D.M., Peters, J.R. and Ashton, T. (2002). Exercise, free radicals, and lipid peroxidation in type 1 diabetes mellitus.
Free Radical Biology and Medicine 33:1543-1551.

2001:
Bailey, D.M., Davies, B., Young, I.S., Hullin, D.A. and Seddon, P.S. (2001). A potential role for free radical-mediated skeletal muscle soreness in the parthophysiology of acute mountain sickness.
Aviation, Space, and Environmental Medicine 6: 513-521.

Bailey, D.M., Davies, B. and Young, I.S. (2001). Intermittent hypoxic training: implications for lipid peroxidation induced by acute normoxic exercise in active men.
Clinical Science 101: 465-475.

Bailey, D.M., Davies, B., Castell, L.M., Newsholme, E.A. and Calam, J. (2001). Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man.
Journal of Applied Physiology 90: 105-113.

Bailey, D.M. and Davies, B. (2001). Acute mountain sickness; prophylactic benefits of antioxidant vitamin supplementation at high-altitude.
High Altitude Medicine and Biology 2: 21-29.

Bailey, D.M. (2001). What regulates exercise-induced reactive oxidant generation; mitochondrial O2 flux or PO2?
Medicine and Science in Sports and Exercise 33: 681-682.

Bailey, D.M. (2001). The ups and downs of high-altitude mountaineering.
British Journal of Sports Medicine 35: 138-139.

Bailey, D.M. (2001). Skeletal muscle catabolism at high-altitude; immunoprotective or immunodepressive?
Aviation Space and Environmental Medicine 72: 1150-1151.

Bailey, D.M. (2001). The last “oxygenless” ascent of Mt. Everest; a mathematical derivation.
British Journal of Sports Medicine 35: 294-296.

2000:
Bailey, D.M., Davies, B., Davison, G. and Young, I.S. (2000). Free radical damage at high-altitude; isolating the source and implications for the pathophysiology of acute mountain sickness.
The Newsletter of the International Society for Mountain Medicine 10: 3-13.

Bailey, D.M., Davies, B., Milledge, J.S., Richards, M., Williams, S.R.P., Jordinson, M. and Calam. J. (2000). Elevated plasma cholecystokinin at high altitude: metabolic implications for the anorexia of acute mountain sickness?
High Altitude Medicine and Biology 1: 9–23.

Bailey, D.M., Davies, B. and Baker, J. (2000). Training in hypoxia; modulation of selected metabolic and cardiovascular risk factors in healthy males.
Medicine and Science in Sports and Exercise 32: 1058-1066.

Bailey, D.M., Castell, L.M., Newsholme, E.A. and Davies, B. (2000). Intermittent and continuous exposure to the hypoxia of altitude; metabolic implications for glutamine metabolism and exercise performance.
British Journal of Sports Medicine 34: 210-212.

1999:
Bailey, D.M. and Davies, B. (1999). Decreased chronotropic drive as an adaptation to chronic exercise; possible mechanisms.
International Journal of Sports Medicine 20: 219-221.

Bailey, D.M. (1999). Does erythrocyte infusion improve 3.2-km performance at high altitude?
European Journal of Applied Physiology and Occupational Physiology 80: 511-512.

Bailey, D.M., Davies, B., Budgett, R., Sanderson, D.C. and Griffin, D. (1999). Intensive training during a twin pregnancy. A case report.
International Journal of Sports Medicine 20: 415-418.

1998:
Bailey, D.M., Davies, B., Williams, S. and Baker, J. (1998). Blood lipid and lipoprotein concentrations in active, sedentary, healthy and diseased males.
Journal of Cardiovascular Risk 5: 309-312.

Bailey, D.M., Davies, B., Romer, L., Castell, L., Newsholme, E. and Gandy, G. (1998). Implications of moderate altitude training for sea-level endurance in elite distance runners.
European Journal of Applied Physiology and Occupational Physiology 78, 360-368.

Bailey, D.M., Davies, B. and Sanderson, D. (1998). Endurance training during a twin pregnancy in an elite marathon runner.
Lancet 351-352, 1182.
Highlighted Paper

1997:
Bailey, D.M., Davies, B., Budgett, R. and Gandy, G. (1997). Recovery from infectious mononucleosis following altitude training in an elite middle distance runner.
British Journal of Sports Medicine 31: 153-154.

Bailey, D.M. and Davies, B. (1997). The effects of altitude training on sea-level endurance performance; a review.
British Journal of Sports Medicine 31: 183-190.

Peer-reviewed guest editorials
Bailey, D.M. (2000). On the mechanisms of acute mountain sickness.
Journal of Wilderness Medicine 4: 10 – 11.

Bailey, D.M. (1999). Acute mountain sickness – the “poison of the pass”.
British Journal of Sports Medicine 33: 376.

Bailey, D.M. (2015). The brain in hypoxia; curiosity, cause and consequence
Experimental Physiology (in preparation).

Guest Editor
Pialoux, V., Bailey, D.M. and Mounier, R. (2012). Hypoxia-induced oxidative stress in health disorders.
Oxidative Medicine and Cellular Longevity.

Peer-reviewed book chapters
Bailey, D.M. Acute mountain sickness and high-altitude cerebral edema.
In: Comprehensive Physiology, American Physiological Society (Ed: Terjung, R.L.)
Wiley-Blackwell (in-the-press)

Bärtsch, P. and Bailey, D.M. Acute Mountain Sickness and High-Altitude Cerebral Edema.
In: Hypoxia: Human Adaptation to High Altitude, Second Edition (Ed: Bärtsch, P. and Swenson, E.R.) Springer-Verlag (in-the-press).

Bailey, D.M. Acute mountain sickness.
In: Encyclopedia of Exercise Medicine in Health and Disease (Ed: Mooren, F.C. and Skinner, J.S.) Springer-Verlag (in-the-press).

Bailey, D.M., Mairbäurl, H., and Bärtsch, P. Molecular mechanisms of acute mountain sickness.
In: Encyclopedia of Molecular Mechanisms of Disease (Ed: Lang, F.) Springer-Verlag: ISBN: 978-3-540-67136-7.

Bailey, D.M., Davies, B., Young, I.S., Hullin, D.A. and Seddon, P.S. (2000). Increased free radical-mediated oxidative stress and skeletal muscle damage at high altitude; a cause or consequence of acute mountain sickness?
In: Proceedings of the 2nd International Congress on Skiing and Science (Ed: Mueller, E.), pp. 2–24.

Bailey, D.M. and Davies, B. (1999). Physiological adaptation to environmental hypoxia; implications for exercise performance.
In: Benefits and Hazards of Exercise (Ed: MacAuley, D.) British Medical Journal Books, London. pp. 277-304.

Peer-reviewed books
Bailey, D.M. Concussion and its impact on the human brain; from molecule to malady
Human Kinetics (in preparation).

Abstracts:
Summary: In excess of 200 abstracts presented to National and International conferences

Memberships

2014-present The European Huntington’s Disease Network
2014-present Welsh Higher Education Brussels
2011-present Neurodem Cymru (Wales Dementias and Neurodegenerative Diseases Research
Network)
2010-present Older People Aging and Stroke Research Networks
2010-present HypoxiaNet
2010-present Pulmonary Vascular Research Institute (Fellow)
2008 Biochemical Society
2008-present Royal Society of Chemistry and Electron Spin Resonance Interest Group (Fellow)
2007-present Birmingham Medical Research Expeditionary Society
2002-present British Association of Sport and Exercise Sciences (past Accredited Research
Physiologist)
2001-2003 British Climatic Physiology Group (c/o Institute of Naval Medicine)
1998-present The Physiological Society
1998-present Medical Expeditions
1998-present American College of Sports Medicine (Fellow)

External

Awards
2015-present Selected as the Science Hero of ADInstruments
2014 William Evans Fellowship (c/o Depts of Surgery and Medicine/School of Physical Education,
Sport and Exercise Sciences, University of Otago, New Zealand)
2013 Selected as Welsh Academic Research Leader
2012 Winner of the Cwm Taff Health Board Annual Research & Development Conference
2011-present Fellow of the American College of Sports Medicine
2010-present Fellow of the Pulmonary Vascular Research Institute
2008-present Fellow of the Royal Society of Chemistry
2008 Young Investigator Award: (Hypoxia: From Integrative Molecular Biology to Clinical Disease, Monte Verità, Ascona, Switzerland)
2007 Young Investigator Award (Birmingham Medical Research Expeditionary Society)
2006 Winner of Welsh FameLab Competition
2002 The Wellcome Trust Young Investigator Award (The Physiological Society)
2000 Scientific presentation to The House of Commons (Young British Scientists)

Editorial Boards
2017-present Editorial Board Member to Journal of Applied Physiology
2015-present Editorial Board Member to Oxidative Medicine and Cellular Longevity
2012-present Editorial Board Member to Dataset Papers in Medicine (Vascular Medicine Section)
2012-present Editorial Board Member to Applied Physiology
2011-present Editorial Board Member to International Journal of Vascular Medicine
2011-present Editorial Board Member to Extreme Physiology and Medicine
2008-present Editorial Adviser to Clinical Science

Visiting Appointments
2015-present Visiting Professor, Sport and Exercise Sciences Research Institute, University of Ulster, N. Ireland
2014-present Visiting Professor, Dept of Medicine, Swansea University, UK
2008-present Visiting Professor, Sondes Moléculaires en Biologie & Stress Oxydant, Institut de Chimie Radicalaire, Aix-Marseille Université, Marseille, France

Committees and consultancy
2015-present Chair of the Elite Performance Working Group for 2016 Olympic Games (c/o Physiological Society)
2014-present Consultant Scientist to the European Space Agency
2014-present External Examiner to Centre of Human & Aerospace Physiological Sciences (MSc Clinical Program), King’s College London
2013-present European Society of Cardiology Member of the Working Group on Atherosclerosis and Vascular Biology
2012-present Stroke Steering Group Member to the Older People Aging Research Network
2012-present Human Science Ethics Committee member (Qinetiq: Ministry of Defence Research)
2010-present Cardiovascular Physiology Lead to the Cardiovascular Research Group Cymru (Welsh Assembly Government)
2010 British representative to the European Hypoxia Society Steering Committee
2009 Accredited Research Physiologist (British Association of Sport and Exercise Sciences)
2009-present University Representative to The Physiological Society
2008-present Lead Physiologist to The British Freediving Association
2008-present Lead of the Oxidative Stress Interest Group (American College of Sports Medicine)
2006-present Research Consultant to The London Altitude Centre (UK)
2001-2003 Secretary to the British Climatic Physiology Group (Institute of Naval Medicine)

Invited keynotes at international conferences (select examples):
Title: Mitochondrial free radical formation and the link to oxygen sensing in-vivo
Meeting: Cardio-Pulmonary Acclimatization and Adaptation to High Altitude: From Physiology to Clinical Practice
Location: Issyk Kul, Kyrgyzstan (September 24th-28th, 2016)

Title: Free radicals and mitochondrial oxygen sensing in humans
Meeting: European College of Sports Sciences
Location: Vienna (July 6th-9th, 2016)

Title: Oxygen, evolution and our radical brains
Meeting: Medipol Medical Biology; Medicine at the Cutting Edge: Translating Scientific Discoveries into Clinical Practice
Location: Istanbul, Turkey (October 27th-28th, 2015)

Title: The brain in hypoxia; curiosity, cause and consequence
Meeting: The Physiological Society Annual Meeting
Location: Cardiff, UK (July 6th-8th, 2015)

Title: Oxygen and the brain
Meeting: American College of Sports Medicine
Location: San Diego, USA (May 26th-May 30th, 2015)

Title: Redox-regulation of vascular endothelial function in hypoxia; from adaptation to maladaptation
Meeting: Experimental Biology (c/o American Physiological Society)
Location: Boston, USA (March 28th-April 1st, 2015)

Title: Oxygen and our gas guzzling brains; from molecules to medals!
Meeting: The 2015 Sports Science Summit
Location: London, UK (January 13th-15th, 2015)

Title: New insights into the regulation of human cerebral blood flow
Acute versus chronic exercise; from damage to neuroprotection
Meeting: American College of Sports Medicine
Location: Orlando, USA (May 28th-31st, 2014)

Title: Oxygen, evolution and the human brain
Meeting: Okanagan Cardiovascular & Respiratory Symposium
Location: Vernon, British Columbia, Canada (March 20th-22nd, 2014)

Title: Mountains of hypoxia; a radical perspective!
Meeting: International Altitude Training Symposium
Location: University of Limerick (March 1st, 2013)

Title: Oxygen, free radicals and the human brain; stressed or sensed?
Meeting: 15th International Conference on Environmental Ergonomics
Location: Queenstown, New Zealand (February 10th-15th, 2013)

Title: Life at the extremes; focus on high-altitude
Meeting: Extreme Environments Symposium
Location: University of Otago, Dunedin, New Zealand (February 7th-9th, 2013)

Title: Oxygen, the brain and acute mountain sickness
Meeting: International Symposium on High-Altitude Tolerance
Location: Heidelberg (January 25th-26th, 2013)

Title: High-altitude illness; a “radical” perspective
Meeting: Medical Expeditions; High-Altitude Medicine and Physiology
Location: University of Oxford (November 30th, 2012)

Title: Boxing and the human brain
Meeting: Royal College of Surgeon’s in Ireland (Society of Neuroscience)
Location: Dublin (November 23rd, 2012)

Title: Physical activity, obesity and cerebrovascular function – train your brain!
Meeting: Obesity and Physical Activity: Olympic Legacy and Evolving Science
Location: Cardiff (November 21st, 2012)

Title: High-altitude cerebral edema
Meeting: International Society for Mountain Medicine
Location: Taipei (November 3rd-6th, 2012)

Title: Go fast, go high, get sick! Oxygen-sensing and exercise at high-altitude
Meeting: American College of Sports Medicine
Location: San Fransisco, USA (May 29th-June 2nd, 2012)

Title: Redox-regulation of cerebral blood flow
Meeting: Canadian Society for Exercise Physiology
Location: Regina, Canada (October 10th-13th, 2012)

Title: Trans-pulmonary formation of free radicals during hypoxia; focus on oxidative-
nitrosative stress
Meeting: 2nd International Symposium on Pulmonary Function in Health and Disease
Location: Giessen, Germany (June 16th-June 18th, 2011)

Title: Oxygen, the “movement-molecule”; from precursors to performance
Meeting: American College of Sports Medicine
Location: Denver, USA (May 31st-June 4th, 2011)

Title: Oxygen, the brain and exercise
Meeting: Oxygen 2011: HypoxiaNet
Location: Davos, Switzerland (January 8th-12th, 2011)

Title: Free radicals as regulators of pulmonary vascular function; from caveats to
controversies
Meeting: Pulmonary Vascular Research Institute
Location: Panama, Central America (February 2nd-5th, 2011)

Title: High-altitude pulmonary hypertension is associated with a free radical-mediated
reduction in pulmonary nitric oxide bioavailability
Meeting: Recent Trends and Future Perspectives in High-Altitude Pulmonary Research
Location: Ladakh, India (September 27th-30th, 2010)
Title: Free radical formation in the human brain at high-altitude

Meeting: The VIII World Congress on High Altitude Medicine and Physiology
Location: Arequipa, Peru (August 8th-12th, 2010)

Title(s): 1. Exercise-induced oxidative-nitrosative stress; measuring its impact on vascular
O2 transport and human performance
2. Is acute mountain sickness a mild form of high-altitude cerebral edema?
3. Redox regulation of cerebral blood flow in hypoxia
Meeting: American College of Sports Medicine
Location: Baltimore, USA (June 2nd-5th, 2010)

Title: Neurobics; oxygen, exercise and the human brain
Meeting: 4th International Symposium for Hypoxia in Medical Research, Training and Rehabilitation
Location: Innsbruck, Austria (January 29th-30th, 2010)

Title: Oxidative stress in the human brain
Meeting: Society for Free Radicals in Biology and Medicine; International Congress on
Free Radicals and Antioxidants
Location: Santiago, Chile (September 27th-30th, 2009)

Title: Is acute mountain sickness a mild form of high-altitude cerebral oedema?
Meeting: 25th Anniversary of Research in High Altitude Physiology and Medicine at the Capanna Regina Margherita
Location: Varallo, Italy, (October 9th–12th, 2008)

Title: Redox-regulation of neurovascular function; focus on hypoxia
Meeting: The Future is Now-Pulmonary Vascular Disease Update
Location: Amsterdam, The Netherlands (April 24th–25th, 2008)

Title: Adventures at high altitude: from the radical (pea) brain to the (leaky) lung!
Meeting: Sensing and Responding to Hypoxia: From Systems to Mitochondria
Location: University College Dublin (March 13th, 2008)

Title: A role for reactive oxygen species in the pathophysiology of high altitude illness?
Meeting: European Congress of Sport Sciences
Location: Lausanne, Switzerland (June 5th-8th, 2007)

Title: Neurological implications of hypoxia; focus on free radical-mediated alterations to
the blood-brain barrier
Meeting: World Congress on High Altitude Medicine and Physiology
Location: San Juan, Argentina (December 1st-3rd, 2006)

Title: The human brain at high-altitude; a radical hypothesis!
Meeting: Dutch Congress on High Altitude Medicine, Past to Present
Location: Nijmegen, Holland (November 10th-11th, 2006)

Title: Free radicals and blood-brain barrier function in acute mountain sickness
Meeting: Hypoxia and Development, Physiology and Disease
Location: Breckenridge, Colorado, USA (January 16th–21st, 2006)

Title: Cytotoxic edema or astrocyte swelling in acute mountain sickness? A critical
perspective
Meeting: Hypoxia: From Integrative Molecular Biology to Clinical Disease
Location: Monte Verità, Ascona, Switzerland (November 25th-30th, 2005)

Title: The radical brain at high-altitude!
Meeting: Expedition Medicine
Location: Royal College of Surgeons, Edinburgh (September 30th, 2005)

Title: Mechanisms and consequences of free radical generation in hypoxia; focus on
electron paramagnetic resonance (EPR) spectroscopy
Meeting: American College of Sports Medicine
Location: San Fransisco, USA (May 27th–30th, 2005)

Title: Inspiratory hypoxia and cerebral fatigue
Meeting: International Symposium on Chronic Fatigue
Location: Tokyo, Japan (November 30th, 2004)

Title: Free radicals in the hypoxic human brain; sources, mechanisms, consequences
Meeting: VI World Congress on Mountain Medicine and High-Altitude Physiology
Location: Xining, Qinghai and Lhasa, Tibet, P.R. China (August 12th–20th, 2004)

Title: Free radicals and exercise performance
Meeting: American College of Sports Medicine
Location: Indianapolis, USA (May 27th–30th, 2004)

Title: Radical di-oxygen; from gas to (unpaired) electrons!
Meeting: International Hypoxia Symposium VIII; Hypoxia: Through the Life Cycle
Location: Banff, Canada, (March 10th–15th, 2003)

Consultancy

Public engagement and media:
Cheltenham Science Festival (c/o The Physiological Society)
http://www.cheltenhamfestivals.com/science/whats-on/2013/will-humans-evolve-in-the-future/

I’m a Scientist Get Me Out of Here! (c/o The Physiological Society)
http://humanj13.imascientist.org.uk/profile/damianbailey/

Winner of Welsh FameLab for science communication
http://www.glam.ac.uk/news/releases/003468.php

Swansea Science Café (Adventures with oxygen; a “radical” perspective)
http://www.swansea.ac.uk/science/swanseasciencecafe/

Learned Society of Wales and Royal Society of Chemistry (Life at the extremes; oxygen, the miracle molecule?)
http://learnedsocietywales.ac.uk/cy/node/450
Wales Online
http://www.walesonline.co.uk/news/health/researchers-play-high-altitude-rugby-matches-2047833

ADI Instruments (Research at High-Altitude)
http://www.adinstruments.com/news/091208/University-of-Glamorgan-Takes-Neurovascular-Research——PowerLab—to-New-Heights/research/

WalesOnline (Kilimanjaro the Killer)
http://www.walesonline.co.uk/news/health-news/2010/04/05/kilimanjaro-can-be-a-killer-91466-26175103/

BBC News Channel (The Brain on Mt. Elbrus)
http://news.bbc.co.uk/1/hi/wales/7506400.stm

London Altitude Centre
http://www.altitudecentre.com/about_us/damian.htm

Migraine Action (The Pea-Brain Hypothesis)
http://www.migraine.org.uk/index.php?sectionid=238

Presentation to Government (Science and the Assembly)
(http://www.geolsoc.org.uk/sata)

Physiological support to Richard Parks who completed a pioneering 7 month race to climb the highest mountain on each of the world’s continents and venture to The South and Geographical North Poles (737 Challenge; seven summits, three poles, seven months) for Marie Cure Cancer Care:
http://www.737challenge.com/
Physiological support to Richard Parks during his Project X Challenge during his attempt to record the fastest solo, unsupported and unassisted journey to the South Pole:
http://www.richardparks.co.uk/
Recently appointed Scientific Leader to the (2016) Richard Parks International Research Expedition to Mt. Everest (Sky News, BBC and Channel 5).

Boxing Action: the voice of boxing
http://boxingaction.com/index.php/component/content/article?id=1543:welsh-university-is-conducting-hi-tech-research-into-effect-of-blows-to-the-head-in-contact-sports

Irish Medical Times (Boxing clever on neuroscience research)
http://www.imt.ie/features-opinion/2012/11/boxing-clever-on-neuroscience-research.html

Rugby Union (in excess of 1,120,000 threads on the www)
Radio 4 and BBC Breakfast News: Brain injury in rugby players
http://news.bbc.co.uk/today/hi/today/newsid_9612000/9612622.stm

Clinical implications of brain injury in rugby union and the link to early-onset dementia:
Interview on Good Evening Wales
http://www.southwales.ac.uk/?content=823

Featured on Week In, Week Out: Rugby’s Hidden Headache on BBC One Wales
http://www.bbc.co.uk/programmes/b04pj7z3

Interviewed on BBC Wales Today and BBC Sport with research mentioned in The Independent
http://www.independent.co.uk/sport/rugby/rugby-union/international/wales-vs-new-zealand-jonathan-davies-thrown-straight-back-in-for-all-blacks-by-warren-gatland-9869200.html

AlJazeera
http://www.aljazeera.com/news/2015/02/concussion-tackled-rugby-150207111610783.html

Selected as the Science Hero of ADInstruments based on cutting-edge research into human ageing (http://www.adinstruments.com/heroes/professor-damian-bailey)

Wales Tonight: Hypoxic brain-train research helping World champion tri-athlete Helen Jenkins prepare for gold in the London 2012 Olympic Games
http://www.itv.com/wales/tri-athlete-helen-jenkins-2012-medal- hopes90777/

Times Education Supplement (Finding gold in the grey matter)
http://www.tes.co.uk/article.aspx?storycode=6257859

Recently appointed Chair of the Elite Performance Working Group for 2016 Olympic Games
(c/o Physiological Society, outreach events ongoing)

Research

Please see previous headings

Areas of Expertise

Oxygen, free radicals and the human brain!

Twitter

https://twitter.com/usw_oxygen

If you are a journalist on deadline and you need to speak with a member of university staff with particular expertise, please contact the Press Office.