Josephine Bradley known as Josie
I am an anatomist and reproductive biologist. My broad research interest is in mechanisms of male and female infertility, however my recent work has focussed on investigating how a high fat diet affects egg quality.
I completed my undergraduate BSc Biomedical Sciences (Anatomy) at Cardiff University in 2012, having undertaken a year in industry in a reproductive biology research lab.
I was awarded Cardiff University’s President’s Research Scholarship in order to continue my studies in reproductive biology as a PhD project titled ‘Label-Free Multiphoton Microscopy of Lipid Droplets in Oocytes, Eggs and Early Embryos’. Here I used a sophisticated multiphoton ‘CARS’ microscope to visualise lipid droplets within mammalian eggs and pre-implantation embryos, in a label-free and chemically-specific manner.
After completing my PhD in 2016, I undertook a BBSRC-funded Research Associate position at Cardiff University in order to continue these studies, focussing on imaging the turnover of fatty acids in mammalian eggs.
Throughout my PhD and Postdoc studies, I maintained a demonstrating and teaching presence within the Cardiff University Wales Centre for Anatomical Education, delivering lectures, and assisting in cadaveric dissection with students from multiple disciplines. Here I gained an enthusiasm for teaching anatomy, which I now deliver at the University of South Wales.
Year 1 – Human Anatomy and Physiology
Year 2 – Human Form and Function; Vertebrate Zoology
Year 3 – Advanced Vertebrate Zoology; Human Structure
Year 2 – Frontiers in Biology
Year 3 – Research Dissertation Supervisor
Jose Raul Gonzalez-Garcia, Josephine Bradley, Michail Nomikos, Laboni Paul, Zoltan Machaty, Anthony Lai and Karl Swann “The dynamics of MAPK inactivation at fertilisation in mouse eggs” (2014) Journal of Cell Science 127, 2749-2760
Josephine Bradley, Iestyn Pope, Francesco Masia, Randa Sanusi, Wolfgang Langbein, Karl Swann, and Paola Borri “Quantitative imaging of lipids in living mouse oocytes and early embryos using CARS microscopy” (2016) Development 143, 2238-2247
Iestyn Pope, Francesco Masia, Josephine Bradley, Kenneth Ewan, Arnica Karuna, Lukas Payne, I. Guschina, John Hardwood, Karl Swann, Trevor Dale, Peter Watson, Wolfgang Langbein and Paola Borri “Coherent Raman Scattering Microscopy: Technology Developments and Biological Applications” (2018) Conference Proceedings: 2018 20th International Conference on Transparent Optical Networks (ICTON) DOI: 10.1109/ICTON.2018.8473706
Josephine Bradley and Karl Swann “Mitochondria and lipid metabolism in mammalian oocytes and embryos, and the clinical implications” (2019) International Journal of Developmental Biology special issue: ‘Early mammalian development: from basic research to clinic’ 63, 93-103
Paola Borri, Josephine Bradley, Iestyn Pope, Wolfgang Langbein and Karl Swann “Imaging lipids in living mammalian oocytes and early embryos by Coherent Raman Scattering microscopy” (2019) SPIE Photonics West 2019 Conference Proceedings: Label-free Biomedical Imaging and Sensing (LBIS) 2019 DOI: 10.1117/12.2506248
Josephine Bradley, Iestyn Pope, Wolfgang Langbein, Paola Borri and Karl Swann “Dynamic label-free imaging of lipid droplets and their link to fatty acid and pyruvate oxidation in mouse eggs” (2019) Journal of Cell Science DOI: 10.1242/jcs.228999
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