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Qualifications

B.Sc.(Hons). PhD.

Responsibilities

  • Senior Lecturer in Infection and Immunity
  • Academic Subject Manager (Biology)


Publications

Powell, Marchbank, Rushmere, van den Berg and Morgan. 1997. Molecular cloning, chromosomal localisation and functional characterisation of the mouse analogue of human CD59. J. Immunol 158,4,1692-1702. Impact Factor 6.9

Kent, Lee, Schedl, Boyle, Fantes, Powell, Rushmere, Abbot, van Heyningen and Bickmore. 1997. Reticulocalbin gene maps to the WAGR region in human and to the small eye Harwell deletion in mice. Genomics 42, 260-267. Impact Factor 3.4

Tomasec, Braud, Rickards, Powell, McSharry, Godola, Cerundolo, Borysiewicz, McMichael, Wilkinson. 2000. Human cytomegalovirus gpUL40 enhances surface expression of HLA-E, an inhibitor of NK cells. Science 287, 1031-1033. Impact factor 24.7

Holt, Powell, Rushmere and Morgan. 2000. Genomic structure and
chromosomal localisation of the gene encoding mouse CD59. Cytogenetics and Cell Genetics. 89. 264-7. Impact Factor 2.5

Book Chapter. “Adenoviral Cancer Gene Therapy”. Powell and Wilkinson. In Viruses, Cell Transformation and Cancer. Advances in Oncobiology Series. 2000

CiarĂ¡n Richardson, Paul Brennan, Martin Powell, Stuart Prince, Yun-Hsiang Chen, Brad Spiller and Martin Rowe. 2005. The susceptibility of B-lymphocytes to adenovirus infection is dependent upon both the Coxsackie-adenovirus receptor and alphavbeta5 integrin expression. Journal of General Virology. 86( 6):1669-79

Dan Forman, Martin Powell, Ed Guy & Nathan West. 2007. Toxoplasma gondii; painting a global picture of an environmentally persistent parasite. Frontiers in Ecology and Environment. Submitted.

Toxoplasma seroprevalence in marine mammals. (2007) West, Powell, Guy, Forman. Manuscript in preparation for Marine Ecology Progress Series. Manuscript in preparation

Toxoplasma incidence and seroprevalence in British free-roaming carnivores.(2007). Powell, West, Guy and Forman. Manuscript in preparation for Veterinary Record

Abstracts and Conference Poster

Ecology and Management of Wildlife Diseases Conference, November 2007.

Dan Forman, Martin Powell, Ed Guy & Nathan West. Toxoplasma gondii; painting a global picture of an environmentally persistent parasite. Chosen for 20min presentation by Dr Forman.

West, N, Powell, M, Guy, E & Forman, D.W. The occurrence of Toxoplasma gondii in British cetaceans. Abstract

Health Protection 2007. Warwick University.

Ed Guy, Martin Powell, Nathan West and Dan Forman. Toxoplasma gondii in the UK: Towards an environmental risk assessment. Poster presentation

Research

Molecular and Disease Ecology of Toxoplasma gondii.

Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, an intracellular protozoan capable of infecting all warm-blooded animals. In humans, infection is generally via the ingestion of infected meat and meat products or contact (direct or waterborne) with the highly infectious oocysts shed in cat faeces. Toxoplasma is generally asymptomatic in healthy individuals but carries a high risk of morbidity and mortality in immunosuppressed individuals (e.g. cancer, AIDS and organ transplant patients) and the foetus. Toxoplasma has also been linked with a greater risk of schizophrenia and other neurological effects.

University of Wales College of Medicine.

Use of adenovirus vectors for the expression of chimaeric T-cell receptors in lymphocytes, a novel gene therapy approach to the treatment of cervical cancer. Generation of recombinant adenovirus vectors expressing chimaeric and native T-cell receptors (TCR) to redirect the killing properties of cytotoxic T-lymphocytes (CTL). Large numbers of tumour-specific CTL could then be generated in vitro for adoptive transfer for cancer therapy.

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