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PhD Molecular Microbiology (Imperial College London)
MRes Biochemical Research (Imperial College London)
BSc Microbiology (University of Nottingham)
Associate Fellow of the Higher Education Academy.


I am a molecular microbiologist experienced in bacterial genetics and genomics. My broad interests are how bacteria interact with each-other in their environment, and how certain species dominate and eliminate competitors.

Rwy’n microbiolegydd moleciwlaidd ag arbenigedd mewn geneteg a genomeg facteria. Yn eang, mae gennyf diddordeb mewn sut mae facteria yn rhyngweithio yn eu amglychedd, a sut mae rhai rhywogaethau yn domineiddio a dlieu eu cystadleuwyr.


Before moving to the University of South Wales I undertook a BBSRC funded Research Associate position at Cardiff University exploring the antimicrobial activity and population biology of Burkholderia bacteria from the Cystic Fibrosis lung. I obtained my PhD from Imperial College London with a thesis on the Type Six Secretion Systems of the opportunistic human pathogen Pseudomonas aeruginosa.

Cyn symyd i Brifysgol De Cymru ymgymherais swydd ymchwil wedi’i ariannu gan y BBSRC ym Mrhifysgol Caerdydd. Pwrpas y gwaith ymchwil oedd archwilio i weithgaredd gwrthfiotig a bioleg poblogaeth facteria Burkholderia o ysgyfaint pobl â ffibrosis systig. Derbyniais PhD o Imperial College, Llundain, gyda traethawd ymchwil ar bwnc secretiad protein o’r pathogen dynol opportunistaidd Pseudomonas aeruginosa.


Module Leader:
Medical Microbiology
Global Challenges in Infectious Disease
Introduction to Forensic Biology

Teaching Contributions:
Human Molecular Genetics
Microorganisms and the Dynamic Cell
Biomedical Research Skills
Research Projects


1: Masschelein J, Sydor PK, Hobson C, Howe R, Jones C, Roberts DM, Ling Yap Z, Parkhill J, Mahenthiralingam E, Challis GL. A dual transacylation mechanism for polyketide synthase chain elease in enacyloxin antibiotic biosynthesis. Nature Chemistry. 2019 Oct;11(10):906-912. doi: 0.1038/s41557-019-0309-7.

2: Webster G, Mullins AJ, Bettridge AS, Jones C, Cunningham-Oakes E, Connor TR, Parkhill J, Mahenthiralingam E. The Genome Sequences of Three Paraburkholderia sp. Strains Isolated from Wood-Decay Fungi Reveal Them as Novel Species with Antimicrobial Biosynthetic potential. Microbiol Resour Announc. 2019 Aug 22;8(34). pii: e00778-19. doi: 0.1128/MRA.00778-19.

3: Mullins AJ, Murray JAH, Bull MJ, Jenner M, Jones C, Webster G, Green AE, Neill DR, Connor TR, Parkhill J, Challis GL, Mahenthiralingam E. Genome mining identifies cepacin as a plant- protective metabolite of the biopesticidal bacterium Burkholderia ambifaria. Nature Microbiology. 2019 Jun;4(6):996-1005. doi: 10.1038/s41564-019-0383-z.

4: Jenner M, Jian X, Dashti Y, Masschelein J, Hobson C, Roberts DM, Jones C, Harris S, Parkhill J, Raja HA, Oberlies NH, Pearce CJ, Mahenthiralingam E, Challis GL. An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics. Chemical Science. 2019 Apr 25;10(21):5489-5494. doi: 10.1039/c8sc04897e.

5: Song L, Jenner M, Masschelein J, Jones C, Bull MJ, Harris SR, Hartkoorn RC, Vocat A, Romero-Canelon I, Coupland P, Webster G, Dunn M, Weiser R, Paisey C, Cole ST, Parkhill J, Mahenthiralingam E, Challis GL. Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis. J Am Chem Soc. 2017 Jun 14;139(23):7974-7981. doi:10.1021/jacs.7b03382.

6: Loveridge EJ, Jones C, Bull MJ, Moody SC, Kahl MW, Khan Z, Neilson L, Tomeva M, Adams SE, Wood AC, Rodriguez-Martin D, Pinel I, Parkhill J, Mahenthiralingam E, Crosby J. Reclassification of the Specialized Metabolite Producer Pseudomonas mesoacidophila ATCC 31433 as a Member of the Burkholderia cepacia Complex. J Bacteriol. 2017 Jun 13;199(13). pii: e00125-17. doi: 10.1128/JB.00125-17.

7: Sana TG, Baumann C, Merdes A, Soscia C, Rattei T, Hachani A, Jones C, Bennett KL, Filloux A, Superti-Furga G, Voulhoux R, Bleves S. Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule Network. MBio. 2015 Jun 2;6(3):e00712. doi: 10.1128/mBio.00712-15.

8: Jones C, Hachani A, Manoli E, Filloux A. An rhs gene linked to the second type VI secretion cluster is a feature of the Pseudomonas aeruginosa strain PA14. J Bacteriol. 2014 Feb;196(4):800-10. doi: 10.1128/JB.00863-13.

9: Jones C, Filloux A. Gene amplification and qRT-PCR. Book Chapter. Methods Mol Biol. 2014;1149:457-68. doi: 10.1007/978-1-4939-0473-0_35.

10: Jones C, Allsopp L, Horlick J, Kulasekara H, Filloux A. Subinhibitory concentration of kanamycin induces the Pseudomonas aeruginosa type VI secretion system. PLoS One. 2013 Nov 8;8(11):e81132. doi: 10.1371/journal.pone.0081132.

11: Lossi NS, Manoli E, Simpson P, Jones C, Hui K, Dajani R, Coulthurst SJ, Freemont P, Filloux A. The archetype Pseudomonas aeruginosa proteins TssB and TagJ form a novel subcomplex in the bacterial type VI secretion system. Mol Microbiol. 2012 Oct;86(2):437-56. doi: 10.1111/j.1365-2958.2012.08204.

12: Hachani A, Lossi NS, Hamilton A, Jones C, Bleves S, Albesa-Jové D, Filloux A. Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteins. J Biol Chem. 2011 Apr 8;286(14):12317-27. doi: 10.1074/jbc.M110.193045


Society for Applied Microbiology
Microbiology Society
Associate Fellow of the Higher Education Academy.


Microbes and Genomes, Cutting Edge Biology: Genetics & Genomics CPD for Teachers. Swansea University / Wales Gene Park / Techniquest. (Oral Presentation). June 2018

Whole genome sequencing insights into the population biology and secondary metabolite capacity of pathogenic Burkholderia gladioli, FEMS Microbiology Congress, Valencia (Poster Presentation) July 2017.

Speaker at Pint of Science Festival, “The past and future of antibiotic discovery” Cardiff, May 2017.

Mining the genomes of Burkholderia bacteria for novel antibiotics. Bioactive Natural Products: Translating promise into practice, Royal Society of Chemistry, University of Oxford (Invited Speaker), July 2016

Darganfod gwrthfiotigau o facteria Burkholderia trwy fanteisio ar eneteg / Exploiting genetics to discover antibiotics from Burkholderia bacteria. Cynhadledd wyddonol Coleg Cymraeg Cenedlaethol. Aberystwyth University (Invited Speaker). Mai 2016

Erthygl BBC Cymru Fyw – Bygythiad mwy na chanser?


Reducing antibiotic use in the meat supply chains- KESS funded project / USW / Feed, Food & Future.

Society for Applied Microbiology- New Lecturer Research Grant 2019


Google Scholar


Areas of Expertise

Antibiotic resistance
Antibiotic discovery
Bacterial genetics
Bacterial pathogenesis
Molecular microbiology



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